Silicosis and methylated arginines/L-arginines: case-control adapted a cross-sectional design

Aim: Silicosis has long been recognized as an important occupational lung disease that is included in the group of pneumoconiosis. As already well-known silicosis a progressive pneumoconiosis characterized by fibrosis lungs. Also, chronic exposure to silica may cause obstructive pulmonary disease, emphysema, cancer, and fibrosis. Asymmetric dimethyl arginine (ADMA), symmetric (SDMA), L-NMMA (NG-mono-methylated-L-arginine) are products protein methyltransferase (PRMT) enzymes. The aim this study investigate relationship between metabolites exposed non-exposed workers.
 Material Method: 180 male subjects (90 workers (age matched-control) 90 diagnosed with physician based on radiological clinical findings history-(silica-exposed) were study. serum levels arginine, ADMA, SDMA, determined using enzyme-linked immunosorbent assay. 
 Results: values significantly higher silica-exposed compared control group. positive correlations observed methylated parameters such ADMA (r=0.43, r=0.60; p